Date of birth: Place of birth:
12.12.1977, Yerevan/Armenia
Education and post doctoral training
1984-1994 High School in Yerevan / Armenia
1995-2000 Study of Pharmacy, Yerevan State Medical University
2000-2001 Pharmacy technician for internship in ’’Pharmex’’ pharmaceutical company, Yerevan, Armenia
2001-2005 Study at the Public Administration Academy as public servant, Yerevan, Armenia
2013 Defend PhD in ’’Biology ’’ science, Ա №06434,
profession is biochemist, Yerevan, Armenia
Title of PhD thesis ”THE OXIDATION PROCESSES AND STRUCTURAL CHANGES IN THE EXPERIMENTAL ANIMAL TISSUES UNDER THE NOISE INFLUENCE AND BEDITIN APPLICATION”
Defense of thesis took place in 9/11/2012, Yerevan, Armenia
Working history and academic positions
2002-2005 Senior laboratory worker at the department of General and Bioorganic chemistry, currently renamed Medical Chemistry, Yerevan State Medical University After Mkhitar Heratsi
2005-2015 Assistant-Professor at the department of Medical Chemistry, YSMU
2010-2015 Scientific researcher in scientific program, YSMU
08/2015-07/2016 Has been awarded a scholarship for the Postdoc Practice by the German Academic Exchange Service (DAAD) at the department of Clinical Pharmacology and at the Department of Medical Genetics of the
Since 09/2016 University Hospital of Tuebingen (Tuebingen, Germany)
Since 09/2016 Assistant-Professor at the department of Medical Chemistry, YSMU
Scientific researcher in scientific program, YSMU
Research interests
The intensity of lipid and protein oxidation processes under the short term noise action (2 hr, 91 dBA level noise), investigate the morphofunctional shifts in immunogenetic organs, structural changes and physico-chemical properties of biomembranes.
Reveal the possible new mechanisms of action of α2-adrenoblocker beditin synthesized in FOCL for the first time and effects of 91 dBA level noise, α-adrenoblockers (beditin, idazoxan and mesedin) mutual effects of noise and α-adrenoblockers on the intensity of lipid peroxidation processes, oxidative modification of the proteins, α-tocopherol content, the quantitative and qualitative composition of phosphoinositides of membranes in white rat tissues.
Study the effects of α2-adrenoblocker mesedin and beditin on the cellular level in different pathological states and models of some genetic diseases such as Alzheimer’s disease, Huntington’s disease.
Completed and ongoing projects
2003-2005 Determination of α-tocoferol content in plasma white rates, the activity of ascorbate-dependent LPO (ADPL-nonenzymathic) system in white rates` membranes by determination of malonyl dialdehyde accumulation, at norm and at short term noise influence (2 hr, 91dBA noise).YSMU, Armenia
2005-2006 Influence of noise on content of membrane individual phospholipids (phosphatidyl ethanolamine, phosphatidyl serine, sphingomyelines, mono-, di-, try-phosphoinositides, lysophosphatidyl choline, phosphatidyl choline) YSU and YSMU, Armenia
2006-2007 Determination of protective action of α2-adrenoblocker beditin on lipid oxidation processes under the short term noise action. YSMU, Armenia
2007-2009 Study the intensity of proteins oxidative modification in serum of experimental animals under the administration of two α-adrenoblockers (beditin, idazoxan), acute acoustic stress conditions and mutual influence of α-adrenoblockers and noise. YSMU, Armenia
2009-2011 Investigation of the morphofunctional shifts in immunogenetic organs (thymus, lymph nodes, spleen) under the short term noise conditions. YSMU, Armenia
2012-2015 Study of physico-chemical parameters of white rat erythrocyte membranes under the condition of acoustic stress. YSMU, Armenia
2012-2015 Study of long term noise Influence on intensity of lipid and protein oxidation processes in blood, on the morphology of immunogenetic organs, on physico-chemical properties of biomembranes. The aim of investigations is to reveal the
2015-2016 possible protective mechanisms of action of α-adrenoblockers beditin and mesedin under the short and long term noise action. Investigate the protective features of α2-adrenoblocker mesedin on the mouse neurons, neural progenitors and astroglial cells in in-vitro models of: 1) hypoxia, 2) glutamate toxicity and 3) Abeta toxicity. To elucidate the age-dependent efficiency of Mesedin to
Since 09/2016 improve the survival and differentiation of aforementioned cell types, cell cultures of different ages were studied. It was also investigated the influence of Mesedin on survival of striatal neurons expressing full length of human Huntingtin (Htt) protein (STHdhQ111/Q111 cell line) as a cellular model of Huntington’s disease.
Study the effects of Mesedin in vivo on APP transgenic mice, particularly on cell neurogenesis, their survival and proliferation, as well as cognitive ability improvement.
Memberships
Since 2004 Armenian Society for Biochemistry
Since 2008 Armenian Association of Biochemists (AAB). The AAB has been accepted as a Constituent member of the FEBS
Since 2010 The ABB became a member (associate adhering body) of the International Union of Biochemistry and Molecular Biology (IUBMB) The AAB became a member (associate adhering body) of the International Union of Biochemistry and Molecular Biology (IUBMB)
Languages: English (good), German (A2) Russian and Armenian (mother tongue)
Marital status: Single